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Cannabis could be a therapeutic treatment for Alzheimer's


Its time to free the weed , This wonderful plant ''Cannabis.

It has multiple benefits for medical patients and then Its other half Hemp can save 100,000s trees everywhere. Anyhow the study below is an abstract of The Potential Therapeutic effects of THC on Alzhemimers disease.




The Potential Therapeutic Effects of THC on Alzheimer's Disease

The Potential Therapeutic Effects of THC on Alzheimer's Disease

JournalJournal of Alzheimer's Disease
PublisherIOS Press
ISSN1387-2877 (Print)
1875-8908 (Online)
SubjectMedicine, Clinical Neurology and Internal Medicine
IssueVolume 42, Number 3 / 2014
Pages973-984
DOI10.3233/JAD-140093
Subject GroupMedicine and Health
Online DateMonday, July 07, 2014

Abstract

The purpose of this study was to investigate the potential therapeutic qualities of Δ9-tetrahydrocannabinol (THC) with respect to slowing or halting the hallmark characteristics of Alzheimer's disease. N2a-variant amyloid-β protein precursor (AβPP) cells were incubated with THC and assayed for amyloid-β (Aβ) levels at the 6-, 24-, and 48-hour time marks. THC was also tested for synergy with caffeine, in respect to the reduction of the Aβ level in N2a/AβPPswe cells. THC was also tested to determine if multiple treatments were beneficial. The MTT assay was performed to test the toxicity of THC. Thioflavin T assays and western blots were performed to test the direct anti-Aβ aggregation significance of THC. Lastly, THC was tested to determine its effects on glycogen synthase kinase-3β (GSK-3β) and related signaling pathways. From the results, we have discovered THC to be effective at lowering Aβ levels in N2a/AβPPswe cells at extremely low concentrations in a dose-dependent manner. However, no additive effect was found by combining caffeine and THC together. We did discover that THC directly interacts with Aβ peptide, thereby inhibiting aggregation. Furthermore, THC was effective at lowering both total GSK-3β levels and phosphorylated GSK-3β in a dose-dependent manner at low concentrations. At the treatment concentrations, no toxicity was observed and the CB1 receptor was not significantly upregulated. Additionally, low doses of THC can enhance mitochondria function and does not inhibit melatonin's enhancement of mitochondria function. These sets of data strongly suggest that THC could be a potential therapeutic treatment option for Alzheimer's disease through multiple functions and pathways.


Authors
Chuanhai Cao1, 2, Yaqiong Li3, Hui Liu1, 2, Ge Bai3, Jonathan Mayl2, Xiaoyang Lin1, 2, Kyle Sutherland4, Neel Nabar5, Jianfeng Cai3
1College of Pharmacy, University of South Florida, Tampa FL, USA
2USF-Health Byrd Alzheimer's Institute, University of South Florida, Tampa FL, USA
3Department of Chemistry, University of South Florida, Tampa FL, USA
4College of Medicine, University of South Florida, Tampa FL, USA
5Thomas Jefferson University, Philadelphia, PA, USA
Keywords
Alzheimer's disease, amyloid-β peptide, cannabinoid, CB1 receptor, CB2 receptor, delta(9)-tetrahydrocannabinol, neurodegeneration



Cannabis shrinks brain? Study says pot abuse damages IQ - Source -RT
http://rt.com/news/204311-usa-cannabis-brain-decrease/

Marijuana compound may halt Alzheimer's disease – study
http://rt.com/news/183948-marijuana-compound-stop-alzheimer/



*Sorry ain't posted much lately '' Computer is dying
 

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