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Short-Term Effects of Cannabis Therapy on Spasticity in MS

RESULTS: Thirty-seven participants were randomized at the start of the study, 30 of whom completed the trial. Treatment with smoked cannabis resulted in a significant reduction in spasticity using an objective clinician-rated measure. The placebo-controlled trial also resulted in reduced perception of pain, although participants also reported short-term, adverse cognitive effects and increased fatigue. No serious adverse events occurred during the trial. The full results of this study can be found here .http://www.cmaj.ca/content/early/2012/05/14/cmaj.110837 ABSTRACT: Multiple Sclerosis (MS) is the most common debilitating neurologic disease of young people, affecting at least 250,000 persons in the US, often between the ages of 20 and 40. Symptom manifestation varies considerably from person to person; however, one frequently noted concomitant is spasticity, which causes pain, spasms, loss of function and difficulties in nursing care. The present application is designed to expl

Vaporization as a "Smokeless" Cannabis Delivery System

The purpose of this study was to evaluate the use of a vaporization system (the Volcano; VAPORMED® Inhalatoren) as a “smokeless” delivery system for inhaled marijuana. The study looked at heating marijuana to form a vapor and then comparing drug levels in the blood to those obtained from smoking an identical amount of marijuana from a cigarette. In addition, we compared the tolerability of the two methods and measured expired carbon dioxide to evaluate whether the vaporizer reduces exposure to respiratory toxins. Eighteen healthy subjects were recruited and admitted to the inpatient ward of the General Clinical Research Center (GCRC) at San Francisco General Hospital to investigate the delivery of marijuana by vaporization compared to marijuana smoked in a standard cigarette. One dose (1.7, 3.4, or 6.8% tetrahydrocannabinol) and delivery system (smoked marijuana cigarette or vaporization system) was randomly assigned for each of the six study days. The analysis suggests that the

Cannabinoids for Neuropathic Pain.

Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a range of experimental neuropathic pain models, and there is mounting evidence for therapeutic use in human neuropathic pain conditions. This article reviews the history, pharmacologic development, clinical trials results, and the future potential of nonsmoked, orally bioavailable, nonpsychoactive cannabinoids in the management of neuropathic pain http://www.ncbi.nlm.nih.gov/pubmed/25160710?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/19789075

Cannabis for Treatment of HIV-Related Peripheral Neuropathy

The full results of this study appear in the February 13, 2007 issue of the journal Neurology . Below is a brief summary of these results. Dr. Abrams and the Community Consortium conducted a study to evaluate the safety and effectiveness of smoked marijuana to treat pain caused by HIV-related peripheral neuropathy (injury to the nerves that supply feelings to your arms and feet). The study evaluated whether marijuana had an effect on pain relief. Marijuana was compared to a placebo; a cigarette that smells and tastes like marijuana but has no active ingredients (THC). The study evaluated both ongoing neuropathic pain (clinical pain) and temporary pain induced by applying heat and capsaicin (ingredient that makes red peppers hot) cream to a small area of the skin (experimental pain). Fifty-five patients were randomized and 50 completed the entire trial. Smoked marijuana reduced daily pain by 34% compared to 17% with placebo. The study concluded that 52% of patients who smoked m

Couples who smoke together Stay together

Husbands and wives who frequently smoke cannabis are less likely to engage in domestic violence than those who consume the drug less regularly, a new study has suggested. So that once again proves cannabis should be controlled & regulated like alcohol. to save our communities from further destruction. Research on the association between marijuana use and intimate partner violence (IPV) has generated inconsistent findings, and has been primarily based on cross-sectional data. We examined whether husbands’ and wives’ marijuana use predicted both husbands’ and wives’ IPV perpetration over the first 9 years of marriage (Wave 1, n = 634 couples). We also examined moderation by antisocial behavior, the spouse’s marijuana use, and whether IPV was reported during the year before marriage. These predictive associations were calculated using a time-lagged multivariate generalized multilevel model, simultaneously estimating predictors of husband and wife IPV. In fully adjusted models, we

Colon Cancer & Cannabis Studies

Cannabis is healing humans suffering from cancer. International Journal of Cancer November 2007 The cannabinoid δ9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells Abstract Deregulation of cell survival pathways and resistance to apoptosis are widely accepted to be fundamental aspects of tumorigenesis. As in many tumours, the aberrant growth and survival of colorectal tumour cells is dependent upon a small number of highly activated signalling pathways, the inhibition of which elicits potent growth inhibitory or apoptotic responses in tumour cells. Accordingly, there is considerable interest in therapeutics that can modulate survival signalling pathways and target cancer cells for death. There is emerging evidence that cannabinoids, especially Δ9-tetrahydrocannabinol (THC), may represent novel anticancer agents, due to their ability to regulate signalling pathways critical for cell growth and

Cannabis World Summit

Educate the nation - Cannabis is the miracle herb - Grows here for us to use to its full potential Keep informing yourself of the benefits of Hemp/Cannabis and share what you learn. Overgrow the world fuel fibers foods....the list goes on it also gets you high Puff Puff Pass Have you ever seen the movie "Pay It Forward"? (watch it if you haven't) It's about a kid who got the bright idea that he could make a positive change in the world by helping a few people, instructing them to help others, and they then are instructed to help others... rinse & repeat. Great inspiring story! This is a grassroots movement (pun intended). There is power in us little-folks. Look at what can happen when we "little guys" pool our tiny resources together. Regardless of what you may think of Obama now, remember, he got to become President of the United States of America by the collective voices and tiny campaign contributions by all the common citizens. H